Amid the peak of respiratory virus season in the U.S., a highly mutated form of SARS-CoV-2 is spreading and contributing to rising cases nationwide: JN.1. JN.1 accounts for more than 20% of all cases in the U.S. and could be more transmissible and better at slipping past people’s immune systems. Here are some questions patients might have about the JN.1 COVID-19 Omicron subvariant, along with the answers that physicians should be ready to share.